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In the context of upper airway epithelial cells, a transcriptomic study of nasal scrape biopsies from e-cigarette users who were former smokers found decreased expression of over 350 genes from a targeted panel of immune-related genes, which demonstrates immune suppression at the level of the nasal mucosa (101)

While both devices are designed to reduce the health risks compared to combustible tobacco products, they function differently and appeal to different preferencese-cigarettes for those who prefer flavoured vapour, and HTPs for those who want a more authentic tobacco experience

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