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Before the promising therapeutic impact of miRNA can be realized, there are several challenges to be addressed, which include but not limited to targeted delivery of oligonucleotides to specific organs, tissues and cell types, poor bioavailability, limited tissue permeability (Stylianopoulos and Jain, 2013), potential drug resistance, and instability (Raemdonck et al., 2008)

Downregulation of EZH2 in Trophoblasts induces decidual M1 macrophage polarization: a potential cause of recurrent spontaneous abortion

The exact mechanisms linking PD and ED are not fully understood, but several factors may contribute to these findings (Figure 2)

The Editors and the authors have concluded that the findings of the paper may be biased