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95 Furthermore, other literature suggests that JS-K inhibits angiogenesis, 96 induces cell apoptosis (a process related to PARP, caspase 8 and 9 cleavage, and cell differentiation), 95,97 destroys double-stranded DNA, 95,9799 and is also able to interfere with the cell cycle and its respective signaling pathways

In vitro data and mouse studies suggest that NE proteolytic activity triggers an inflammatory process that induces goblet cell metaplasia, which results in overexpression of mucins that contribute to the symptomatology of CRS (66, 67)

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