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Nature 327 239242

Acknowledgements This work was supported by the Plans for Major Provincial Science & Technology Projects (202303a07020002 to Z.Z.), the National Key Research and Development Program of China (STI2030-Major Projects 2021ZD0203100 to Z.Z.), the National Natural Science Foundation of China (32025017 to Z.Z., 32121002 to Z.Z., 32400824 to P.C., 32522044 to P.C., U24A20702 to P.C.), the Anhui Provincial Natural Science Foundation (2308085QH264 to P.C.), the CAS Project for Young Scientists in Basic Research (YSBR-013 to Z.Z.), the Fundamental Research Funds for the Central Universities (WK9100250108 and WK9100000068 to P.C.), and the USTC Research Funds of the Double First-Class Initiative (YD9100002501 to Z.Z.)

Similarly, losing a lot of weight or becoming underweight (BMI less than 20) can delay periods as well, particularly in the context of any disordered eating

The new framework represents an important shift in how innovative therapies are assessed, strengthening collaboration between EU Member States through Joint Clinical Assessments while placing greater emphasis on outcomes that matter to patients and healthcare systems