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Those with an additional psychiatric comorbidity other than MDD, those with any cardiac disease and any ischemic disease that may affect IMA level, those with chronic disease or neurological disease that may affect oxidative stress parameters, those with limited mental capacity and pregnant women were not included in the study because they may confound the study results

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doi: 10.7759/cureus.14617 Coogan PF, Bethea TN, Cozier YC, et al

Nevertheless, GA is considered more effective and safer than TCA peeling for melasma [99, 106], while JS and RA peels are low-cost and safe adjuvant procedures for melasma