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Rodents consuming prebiotics like bovine milk oligosaccharides, oligofructose-enriched inulin, spirulina platensis, and a combination of Fructooligosaccharide/Galactooligosaccharide have exhibited decreased plasma levels of lipopolysaccharides, lower serum concentrations of pro-inflammatory cytokines, diminished intestinal inflammation, and enhanced tight-junction integrity [93,94,95,96,97]

J Med Chem

This needs medical attention, not watchful waiting

Therefore, considering the presence of APAP protein adducts at the therapeutic dose of APAP, formation of protein adducts on mitochondrial proteins rather than the overall formation of protein adducts may be the reason for cellular toxicity, which has been considered a key factor for necrotic cell death in previous years (Jollow et al., 1973