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6 The screening model is valuable precisely because it is sensitive, but that sensitivity is also its limitation: many agents that look promising on dermal papilla cells never translate into clinically meaningful regrowth, because a follicle in a dish is insulated from the hormonal, vascular, immune, and mechanical realities of a living scalp

The oxidation of PDI by Ero1 is thought to occur through disulphide exchange that results in the formation of reduced Ero1 (Gross et al , 2004)

We might give higher initial doses, followed by a regular maintenance plan

Therefore we have various antioxidant mechanisms (detailed later) that prevent too much hydrogen peroxide from accumulating during respiration