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Since then, there is a growing interest to develop newer and safer treatments to achieve the same whitening effect

The C-terminal regulatory domain of ModE is actually two subdomains, each corresponding to a Mop sequence similarity region

While overall urinary GSH levels before and after the treatment did not show a significant difference (Supplemental Figure 16A), a significant decrease in urinary GSH levels was observed in seven patients who experienced more than a 50% reduction in urinary protein levels after steroid treatment (Supplemental Figure 16B)

Since these proteins are mainly regulated post-translationally (e.g., via phosphorylation), mRNA levels may not fully reflect pathway activation