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25-OHC treatment significantly inhibited sterol regulatory element-binding protein (SREBP) expression in IMS32 Xuewang cells, downregulated GXP4 and stearoyl-CoA desaturase 1 (SCD1), and upregulated PTGS2, thereby increasing intracellular ROS levels and promoting ferroptosis

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The FDA does not conduct clinical trials or attempt to discover new treatments, but rather requires companies or other entities to fund marketing approvals

A post-mortem study found lower levels of GSH in patients with MDD specifically in the prefrontal cortex (PFC) (Gawryluk et al