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However, supplementation with 0.1 mM Epitalon notably reduced the incidence of fragmentation from 13% in the aged group to 5.8%

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Recently, our group has demonstrated that PD mimetics including 6-hydroxydopamine (6-OHDA), N-methyl-4-phenylpridine (MPP + ) and rotenone suppressed mTOR signalling, accelerated cleavage of caspase-3 and PARP in PC12 cells and primary neurons and subsequently triggered neuronal apoptosis