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In the final step of glutathione synthesis, glycine is added to the glutamate-cysteine pair to complete the tripeptide

Moreover, we performed WB analysis on tumor and various organs, including the heart, liver, spleen, lung, and kidney, and found that the expression level of LAT1 in the tumor was significantly higher than in other tissues, such as the liver and kidney (Supplementary Fig

This may be explained by the findings of Albares and colleagues, Guinot and colleagues, and Kang and colleagues , who reported that pregnancy, use of hormonal contraception and lack of use of sunscreen are aggravating factors of melasma due to increase number and activity of melanocyte in epidermis