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Tumor cells, tumor-associated macrophages, and certain dendritic cells can decrease local tryptophan levels by provoking metabolic enzymes, including indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO2) (130)

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X-linked gene with mosaic expression in females Conversion of 6-phosphogluconolactone to 6-phosphogluconate by lactonase : irreversible Conversion of 6-phosphogluconate to ribulose-5-phosphate by 6-phosphogluconate dehydrogenase : irreversible NADPH produced, CO 2 released Reactions of the Non-Oxidative Phase: Interconversion of ribulose-5-phosphate and xylulose-5-phosphate by phosphopentose epimerase (ribulose-5-phosphate epimerase) : reversible Interconversion of ribulose-5-phosphate and ribose-5-phosphate by phosphopentose isomerase (ribose-5-phosphate ketoisomerase) : reversible Ribose is a major component of nucleic acids

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