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Clinical implication Although the association between GLP-1 RAs and gallbladder/biliary diseases has been supported by multiple studies, causality has not been definitively established

For researchers interested in exploring related metabolic peptides, compounds like AOD 9604 offer complementary research opportunities in fat metabolism pathways

Yen, Head of the Laboratory of Hormonal Regulation at Duke-NUS' Cardiovascular & Metabolic Disorders Programme, and senior author of the study, said, "The potential for using vitamin B12 and folate, which have high safety profiles and are designated as dietary supplements by the US Food and Drug Administration, as first-line therapies for the prevention and treatment of NASH could result in tremendous cost savings and reduce the health burden from NASH in both developed and developing countries." Currently, the only treatment for patients with end-stage liver disease is to receive a transplant

Maintenance phase: Once the initial phase is completed, the frequency of lipotropic injections may be reduced