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The ISO is a beta-adrenergic receptor agonist, which may produce free radicals in the heart and develop MI-like symptoms in experimental animals 12

Published in Diabetologia (Blher and colleagues, NCT04153929), this Phase 2 trial randomized 413 adults with type 2 diabetes on background metformin to survodutide across several once-weekly or twice-weekly dose groups, to placebo, or to open-label semaglutide up to 1.0 mg once weekly

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