The difference lies in how these compounds bind to plasma proteins and are stored in the liver
C., Werner, S., Barrandon, Y., & Longaker, M
de Koning, A E
Bacterial infections are among the most life-threatening healthcare challenges, accounting for approximately 13.6% of global mortality and affecting 1 in 8 individuals worldwide ( Beyond their pathogenic roles, bacteria are integral to human health, especially in the gut, contributing to immune modulation and digestion ( The human microbiome, especially the gut microbiota, comprises numerous symbiotic bacterial species (e.g., Lactobacillus , Bacillus , Clostridium , Enterococcus , and Ruminococcus ) that collectively represent approximately 90% of the gut flora ( While antibiotics effectively eliminate harmful pathogens, their indiscriminate targeting also affects beneficial bacteria, reducing microbial diversity and increasing the likelihood of antibiotic resistance ( The decreasing efficacy of antibiotics and the limited availability of alternative treatments underscore the urgent need for new classes of antibacterial therapeutics
