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Further studies showed that the significant life span extending effects of EGCG on nematodes could be attributed to its free radical scavenging effect in vitro and in vivo and its upregulation of SOD-3 and HSP-16.2 [103]

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TB-500 (a Thymosin Beta-4 fragment) acts as a G-actin sequestering peptide affecting cytoskeletal remodelling and cell migration, with effects measured at the actin polymerization level rather than at receptor-pathway level

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