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Activation of the TLR9-MyD88 signaling axis leads to NF-B activation and the production of proinflammatory cytokines such as IL-6 and TNF-, further amplifying antibacterial responses

As an important component of regulating metabolism and immune homeostasis, the vagus nerve can regulate WAT content through the central nervous system to control sympathetic peripheral muscle bundles, and can also regulate the release of GSH and NO to enhance antioxidant capacity and prevent ferroptosis (103)

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It helps trigger growth hormone pulses without significantly affecting other hormones