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Hyperforin, kaempferol, luteolin, and quercetin are the core active ingredients of SJC, Molecular modeling studies further confirmed that AKT1 , caspase 3 ( CASP3 ), IL6 , IL1B , Jun proto-oncogene ( JUN ), MAPK3 , prostaglandin-endoperoxide synthase 2 ( PTGS2 ), TNF , and vascular endothelial growth factor A ( VEGFA ) are the core targets of these four active ingredients, which helped reveal the antidepressant mechanism of SJC [35]

The formula seemed to work when applied before UVB exposure and, to some extent, after exposure