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Animal studies, like the one cited with rat models, consistently show recovery of tendon-to-bone and muscle-to-bone junctions that normally fail to heal spontaneously

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However, in cases of chronic microbial dysbiosis induced by exposure to environmental toxicants, ingestion of a high-fat diet can cause changes in the GI environment that can enable distinct microbes to proliferate and infiltrate neighboring gut environments, and subsequently trigger deleterious inflammatory pathways (Figure 1) (Sun et al., 2018