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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

6.2 Methionine restriction (MR) CR reduces oxidative stress and increases lifespan in many species

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No significant negative interactions have been documented between AOD-9604 and commonly used peptides