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The first evidence demonstrating the role of the N-terminus of JAK2 in receptor interactions was shown using JAK2 mutants, lacking the 239 N-terminal residues that rendered the JAK2 mutant incapable of binding GHR or the membrane proximal region of the common chain (64, 65)

Representative tissue sections were processed for further histological analysis as described previously (30-33)

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Tablets may take slightly longer to break down in your digestive system, whereas capsules typically dissolve more quickly