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However, cellular senescence may also exhibit a protective effect in the context of AKI, as evidenced by certain small-molecule inhibitors which can induce proximal tubule cell-cycle arrest that have been found to improve kidney injury outcomes in murine models ( 4.2 Chronic kidney disease According to the latest KDIGO (Kidney Disease: Improving Global Outcomes) 2024 guidelines, CKD is defined as abnormal kidney structure or function, lasting at least 3 months, which has an impact on health

CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP Cascade1

Therefore, it is necessary to choose a suitable ratio of acid to alcohol substances