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Thrombospondins as key regulators of synaptogenesis in the central nervous system

Primary search terminology included esculetin, 6,7-dihydroxycoumarin, and cichorigenin, combined with disease-specific or mechanism-based terms including esculetin AND inflammation, esculetin AND cancer, esculetin AND diabetes, esculetin AND antioxidant, coumarin AND bioavailability, and coumarin AND derivatives. Disease-specific searches incorporated relevant MeSH headings (neoplasms, cardiovascular diseases, diabetes mellitus, neurodegeneration, and hepatic/renal disorders)

Keywords: Epithalon, Epitalon, Synthetic Tetrapeptide, Pineal Peptide Analogue