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S.BrcicL.et al (2013)

Heldmaier, G

Peroxisome proliferator-activated receptor alpha (PPAR), a key nuclear transcription factor that regulates keratinocyte differentiation and epidermal lipid metabolism, is markedly downregulated in AD (Kuai et al., 2024), leading to impaired barrier integrity and defective lipid synthesis, which further supported by PPAR agonist-induced barrier restoration in ex vivo skin model (Majewski et al., 2021)

They concluded that GSH is the primary sulfur receptor of SQOR in vivo , and proposed a simplified pathway in which SQOR oxidizes H 2 S to generate glutathione persulfide (GSSH), which is then converted to sulfite and sulfatethus avoiding the need for sulfite to directly cross membranes ( 2 S oxidation flux in liver and heart, respectively