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Goodman and Gilman's Pharmacological Basis of Therapeutics Digital Edition

Enzymes like NADPH oxidases, xanthine oxidases, cytochrome P450 and other oxidases also produce ROS

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Oxidative stress can damage lipids, proteins, and DNA, which can cause cellular dysfunction and tissue damage ( A crucial part of physiological balance is the complicated relationship between antioxidants in the diet and oxidative stress-induced adrenal hormone imbalance ( The primary objective of this review is to elucidate the mechanisms by which adrenal hormone imbalance induces oxidative stress and investigate the potential contributions of nutritional antioxidants in mitigating such imbalances