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In this study, 29.7% of patients discontinued DMTs, of which 89% of patients remained off treatment, and only one clinical relapse occurred among those who discontinued DMTs

DOI: 10.1016/j.mam.2016.11.003 46

Using systematic proxy data, including sea surface temperature, atmospheric CO 2 and sedimentary observations such as climatically sensitive minerals/facies, HadCM3BL successfully established robust simulations across the PTME interval that shows a mega-El Nio and stronger temperature fluctuations both on land and in the ocean due to the collapse of meridional overturning circulation and a contracted Hadley cell 3