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The most important functions of the skin, which are widely known, include the mentioned protective function as well as the body's thermoregulatory function, participation in water and excretory balance, involvement in the synthesis of proteins and certain compounds, and participation in the metabolism of proteins, lipids, and carbohydrates

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Hold isotretinoin and consult a hepatologist if ALT or AST reaches three times the upper limit of normal [2]

doi: 10.1038/cdd.2017.159 17 GuizeRLiuVMRosebrockDJourdainAAHernndez-SnchezMMartinez ZuritaAet al