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This mirrors studies in transplant and non-transplant populations where increases of 510 MELD-3 points over weeks to months substantially increase short-term mortality risk ( Baseline serum albumin emerged as the only independent predictor of mortality in the main Cox model, and infections and hepatic encephalopathy during follow-up were strong predictors in the extended model

Therefore, IGF-I deprivation contributes to the progressive malnutrition in chronic liver disease patients, increasing the vulnerability of the liver to an inflammatory and oxidative microenvironment that increases the risk of cirrhosis development

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