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This, together with our findings demonstrating the role of the adrenergic system in the regulation of SS [54, 61], allows to hypothesize that the action of E2 on SS neurons depends on its effects on adrenergic transmission to these neurons [4]

Furthermore, BPC 157s effect on endothelium, in addition to its strong interactions with the NO system (for a review, see [3]) is strongly supported by the most recent demonstration that BPC 157s effect on vasomotor tone is carried out through BPC 157-specific activation of the SrcCaveolin-1endothelial nitric oxide synthase (eNOS) pathway [81]