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LGD-4033 A randomized controlled trial found LGD-4033 to be well-tolerated in 76 healthy men after receiving dosages of 0.1, 0.3, or 1 mg per day for 21 days

Here two different pharmacological agents known to induce gut permeability (ethanol and AT1002, a Vibrio cholerae zonula occludens toxin hexapeptide) were used to induce transient increase in gut permeability in mice before their exposure to experimental colitis

SAXS is a rather widely used technique for characterizing IDPs