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Many ip genes had been identified in T-even phage genomes by detection of the signal sequence, but only one had been functionally characterized: Ip1 in phage T4 is an inhibitor of a Type IV restriction endonuclease (RE) known as GmrSD, which specifically cleaves glucosyl-hydroxymethylcytosine (g-hmC)-modified DNA typical of T-even phages (T2, T4, T6) 29

This dose is often enough to treat most deficiencies

In the mild-episodic form of GCE, patients present in childhood with mild intellectual impairment

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