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staggered titration Cycle driver GI tolerance sets the pace Retatrutide Loading 2 mg 4 mg 8 mg (weeks 1-12) Frequency Once weekly Maintenance 12 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Retatrutide 12 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once-weekly

Tirzepatide population pharmacokinetics and exposure Schneck 19-study pooled popPK (CL/F 0.061 L/h, half-life 5.4 d, accumulation 1.7x, body-weight covariate +22% at 70 kg / -33% at 120 kg)

In addition, BPC 157 reduces severe encephalopathies (NSAID overdose, Medvidovic-Grubisic et al., 2017))