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The bioconjugation of the aptamers onto the nanoparticulate systems can be attained via non-covalent (affinities interaction e.g., streptavidin-biotin or metal ion co-ordination) and covalent (1-ethyl-3-carbodiimide or succinimdyl ester-amine chemistry and N -hydroxysuccinimide activation chemistry which cross link the carboxylic acid group on the surface of the nanoparticles and the amino group of the ligands) interactions

Washington, DC: American Psychiatric Association

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