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We are entirely dependent on dietary intake or supplementation, and even with adequate dietary intake, absorption can be impaired by a range of factors including age-related changes to stomach acid production, certain medications, and digestive conditions

Glutathione functions as a key antioxidant that neutralizes reactive oxygen species, but its reserves diminish with age, making supplementation advisable

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Abstract Uncontrolled oxidative stress, reported in Salmonella and HIV infections, colorectal cancer or severe acute malnutrition, has been associated with anaerobic gut microbiome alteration, impaired butyrate production, mucosal immunity dysregulation and disruption of host-bacterial mutualism