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Most features of CKD-MBD are usually present by the time eGFR falls below 45 (stage 3b), though bone disease can begin as soon as stage 2 (eGFR 60 to 89)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Langley R.J., Tsalik E.L., van Velkinburgh J.C., Glickman S.W., Rice B.J., Wang C., Chen B., Carin L., Suarez A., Mohney R.P., et al

Children under 15 years of age follow dosage by your doctor