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Description

The three compounds, in a rigorous research approach, require: strict analytical control (MS + HPLC 98%), adapted administration route (intranasal for BBB crossing), standardised behavioural model with positive control, and exhaustive documentation for publication

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(2024) Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis Haider SH, Irfan A, Sheikh SM, et al

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Preclinical research Much of the published literature involves cells and animal models rather than controlled human studies

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This hypothesis is supported by emerging data but has not been definitively confirmed in large trials

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