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Landmark clinical trial series, such as the ALADIN and SYDNEY trials, have consistently demonstrated that ALA significantly reduces the positive symptoms of diabetic peripheral neuropathy, including lancinating pain, burning, and numbness

27,28 In addition to targeting Wnts, some regulators can directly or indirectly activate FZD and LRP5/6 receptors, such as R-spondins, Norrin, and DKKs, and all of them are secreted proteins

Finally, we discuss the possible impact of Nrf2 inhibitors on cancer therapy

These materials can effectively deliver small molecules, enabling their application in the clinical treatment of liver diseases, demonstrating promising therapeutic outcomes while mitigating systemic drug toxicity [227]