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The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

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Prospective mechanisms include high-frequency patterns obscuring encoded information, suppression of abnormal beta oscillations, stimulation of inhibitory gamma-aminobutyric acid (GABAergic) afferents to the nucleus in focus, efferent projections or passing fibers, and the inhibition of neurotransmitter and hormone production or release