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A clinical study has shown that female E4 carriers who experienced late life weight loss were at an increased risk of developing dementia but not males (Kristoffer et al., 2015)

5.3.1.2 Microglia and AD The pathological significance of activated microglia in the brains of AD patients was first systematically described by McGeer and colleagues in 1987, a discovery that ignited extensive investigation into their potential role in neurodegenerative progression