Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth
It should be used with caution in neonates, premature infants, children, and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 70 years and above) after consulting the doctor
In contrast, cuproptosis represents a separate copper-dependent pathway in which excess copper directly targets mitochondrial metabolism, inducing cell death through aggregated lipoylated proteins and iron-sulfur (Fe-S) cluster loss, independent of apoptotic signaling [3, 8]
Mori, M., Kuroda, T., Obana, A., Sakata, I., Hirano, T., Nakajima, S., Hikida, M., & Kumagai, T