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The compound Ras-selective lethal 3 (RSL3, Figure 2D), which can covalently bind to the selenocysteine (Sec) at the active site of GPX4 and inhibit its activity, is a highly effective ferroptosis inducer (Dixon et al., 2012)

Its selective action on adipose tissue, minimal systemic effects, and ability to mobilize energy stores make it invaluable in metabolic and obesity-related research

Tang D, Kang R (2023) From oxytosis to ferroptosis: 10 years of research on oxidative cell death

Supplements and Down syndrome There are mixed data regarding whether people with Down syndrome require the active forms (versus inactive forms) of vitamin B12 and folate when taking a supplement