Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Chen et al., 1998)
Natures Sunshine skillfully embraced this activation process, and seeing how the brand appears now in market is impressive. To succeed, Natures Sunshine needed a construct of how it would communicate the new brand strategy to its target consumers
Arbeiter AK, Kranz B, Wingen AM, Bonzel KE, Dohna-Schwake C, Hanssler L, Neudorf U, Hoyer PF, Bscher R (2010) Continuous venovenous haemodialysis (CVVHD) and continuous peritoneal dialysis (CPD) in the acute management of 21 children with inborn errors of metabolism
Understanding muscle dysfunction in chronic fatigue syndrome