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Cagrilintide monotherapy weight loss In the phase 2 trial over 26 weeks, cagrilintide weight loss ranged from 6.0% to 10.8% of body weight depending on dose

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Nrg4/cGAS/STING Neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family [104] abundantly expressed in brown adipose tissue, binds to and activates the Epidermal Growth Factor Receptor 4 (ErbB4) receptor tyrosine kinase [105], playing a critical role in various physiological and pathological processes including alleviating non-alcoholic fatty liver disease by inhibiting inflammatory factor levels, improving obesity, and optimizing lipid metabolism