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Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimers disease

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For the ICC research with HepG2 cells, human and rabbit HPX isolated by the Smith group was used (500 nM), except for the ICC studies on binding and uptake in Figures 3, 5, where proto-hemehuman HPX (CSL) was increased to 1 M (Figure 3) or 2 M (Figure 5) to increase the signal intensity

Respiration calculations following the Mito Stress Test were performed following previously published recommendations by the manufacturer and others 51,136,137