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With respect to the cost criterion, the applicant provided two analyses to demonstrate that VEST meets the cost criterion, the first using 100 percent of all identified cases, and the second using 78 percent of all identified cases, based on the four MS-DRGs with the highest number of claims

Brenner, M

Tirzepatide has been extensively documented in the SURMOUNT-1 trial, which observed significant reductions in baseline body mass in subjects over a 72-week period

Abnormal and constant activation of myofibroblasts causes secretion of extracellular matrix (ECM) metabolites, leading to excessive ECM deposition and PF formation (Pi et al., 2023)