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IGF-1 mediates the anabolic actions of growth hormone and is a critical regulator of muscle regeneration and repair. Philippou et al., BioMed Research International How IGF-1 LR3 Differs from Regular IGF-1 Because of its long duration and enhanced activity , IGF-1 LR3 is often used in cutting-edge performance stacks , especially when paired with GH secretagogues, SARMs, or anabolic agents