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While balanced concentrations of Fe 2+ are essential for the survival of living organisms, iron overload is responsible for the generation of metabolically toxic ROS and phospholipid hydroxy peroxides through the Fenton reaction, ultimately leading to cell damage and death by ferroptosis [16, 17]

Wrist arthritis, whether osteoarthritis or rheumatoid arthritis, can cause pain, stiffness, and swelling in the wrist joint as the protective cartilage wears down or becomes inflamed

In low-income areas, the age-standardized stroke-related mortality rate is 3.6 times higher than that in high-income areas (Collaborators, 2021)