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For example, De Blasio and his co-workers demonstrated that Nrf2 upgraded both the proliferation and antioxidant capacity in triple-negative breast cancer (TNBC) cells by downmodulating miR-29b-1-5p expression

Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation

doi:10.1110/ps.041293005

The Senescence-Associated Secretory Phenotype (SASP) One of the most impactful features of senescent cells is their acquisition of a complex secretome known as the SASP [55]