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The peptide suppresses formation of pro-inflammatory mediators including TGF-1, creating an environment conducive to regeneration rather than chronic inflammation

RNA concentrations were determined by OD measurement at 260 nm on a spectrophotometer (Implen), and cDNA was synthesized from the purified RNA by both random and oligo (dT) priming using an iScript cDNA synthesis kit (TIANGEN)

Several questions remain unanswered, including the association between irAEs onset and the type of organ system toxicities, toxicity grading, ITBs, confounding comorbidities like autoimmune diseases, immune heterogeneity and patient intrinsic factors