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Underlying mechanisms may include chronic airway inflammation, impaired mucociliary clearance, increased bronchial hyperresponsiveness, increased development of T helper cell 2 (Th2) pathways relative to Th1 pathways, increased production of IgE, and greater allergic sensitization [9,25]
The combination of using both substances can lead to unpredictable side effects and potentially dangerous risks of other health conditions
The use of cigarettes became increasingly widespread after the Crimean War, when British soldiers began emulating Turkish comrades and Russian enemies
The agreement didn't ban candy cigarettes, but it so greatly reduced the visibility of tobacco (after public pressure on tobacco companies to comply with the agreement, which is another story) that the image of tobacco as something cool to be mimicked with candy waned even more
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